Medicines and Related Substances Act, 1965
R 385
Occupational Health and Safety Act, 1993 (Act No. 85 of 1993)RegulationsHazardous Chemical Substances Regulations, 1995Annexure 1Biological Exposure Indices |
Acetone
|
Determinant |
Acetone in urine |
|
Sampling Time |
End of shift |
|
BEI |
100 mg/l |
|
Notation |
B , C |
Aniline
|
Determinant |
Total p-aminophenol in urine |
|
Sampling Time |
End of shift |
|
BEI |
50 mg/g creatinine |
|
Notation |
C |
|
Determinant |
Methemoglobin in blood |
|
Sampling Time |
During or end of shift |
|
BEI |
1.5% of hemoglobin |
|
Notation |
B, C, D |
Arsenic and soluble compounds, including Arsine
|
Determinant |
Inorganic arsenic metabolites in urine |
|
Sampling Time |
End of workweek |
|
BEI |
50 mg/g creatinine |
|
Notation |
B |
Benzene
|
Determinant |
Total phenol in urine |
|
Sampling Time |
End of shift |
|
BEI |
50 mg/g creatinine |
|
Notation |
B, C |
Benzene in exhaled air:
|
Determinant |
Mixed exhaled |
|
Sampling Time |
Prior to next shift |
|
BEI |
0.08 ppm |
|
Notation |
D |
|
Determinant |
End exhaled |
|
BEI |
0.12 ppm |
Cadmium
|
Determinant |
Cadmium in urine |
|
Sampling Time |
Not critical |
|
BEI |
10 mg/g creatinine |
|
Notation |
B |
|
Determinant |
Cadmium in blood |
|
Sampling Time |
Not critical |
|
BEI |
10 ug/l |
|
Notation |
B |
Carbon Disulphide
|
Determinant |
2-Thiothiazolidine-4-carboxylic acid (TTCA) in urine |
|
Sampling Time |
End of shift |
|
BEI |
5 mg/g creatinine |
Carbon Monoxide
|
Determinant |
Carboxyhemoglobin in blood |
|
Sampling Time |
End of shift |
|
BEI |
< 8 % of hemoglobin |
|
Notation |
B, C |
|
Determinant |
CO in end exhaled air |
|
Sampling Time |
End of shift |
|
BEI |
< 40 ppm |
|
Notation |
B, C |
Chlorobenzene
|
Determinant |
Total 4-chlorocatechol in urine |
|
Sampling Time |
End of shift |
|
BEI |
150 mg/g creatinine |
|
Notation |
C |
|
Determinant |
Total p-chlorophenol in urine |
|
Sampling Time |
End of shift |
|
BEI |
25 mg/g creatinine |
|
Notation |
C |
Chromium (VI)
|
Determinant |
Water soluble fume |
|
Sampling Time |
Increase during shift |
|
BEI |
10 ug/g creatinine |
|
Notation |
B |
|
Determinant |
Total chromium in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
30 ug/g creatinine |
|
Notation |
B |
N,N-Dimethylformamide (DMF)
|
Determinant |
N-Methylformamide in urine |
|
Sampling Time |
End of shift |
|
BEI |
40 mg/g creatinine |
|
Notation |
B |
2-Ethoxyethanol (EGEE)
|
Determinant |
2-Ethoxyacetic acid in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
100 mg/g creatinine |
2-Ethoxyethylacetate (EGEEA)
|
Determinant |
2-Ethoxyacetic acid in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
100 mg/g creatinine |
Ethyl Benzene
|
Determinant |
Mandelic acid in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
1.5 g/g creatinine |
|
Notation |
A |
|
Determinant |
Ethyl benzene in end exhaled air |
|
Notation |
D |
Flourides
|
Determinant |
Flourides in urine |
|
Sampling Time |
Prior to shift |
|
BEI |
3 mg/g creatinine |
|
Notation |
B, C |
|
Sampling Time |
End of shift |
|
BEI |
10 mg/g creatinine |
|
Notation |
B, C |
Furfural
|
Determinant |
Total furoic acid in urine |
|
Sampling Time |
End of shift |
|
BEI |
200 mg/g creatinine |
|
Notation |
B, C |
n-Hexane
|
Determinant |
2,5-Hexanedione in urine |
|
Sampling Time |
End of shift |
|
BEI |
5 mg/g creatinine |
|
Notation |
C |
|
Determinant |
n-Hexane in end-exhaled air |
|
Notation |
D |
Lead
|
Determinant |
Lead in blood |
|
Sampling Time |
Not critical |
|
BEI |
50 mg/100 ml |
|
Notation |
B |
|
Determinant |
Lead in urine |
|
Sampling Time |
Not critical |
|
BEI |
150 mg/g creatinine |
|
Notation |
B |
|
Determinant |
Zinc protoporphyrin in blood |
|
Sampling Time |
After 1 month exposure |
|
BEI |
250 mg/100 ml erythrocytes or 100 ug/100ml blood |
|
Notation |
B |
Mercury
|
Determinant |
Total inorganic mercury in urine |
|
Sampling Time |
Preshift |
|
BEI |
35 mg/g creatinine |
|
Notation |
B |
|
Determinant |
Total inorganic mercury in blood |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
15 mg/l |
|
Notation |
B |
Methanol
|
Determinant |
Methanol in urine |
|
Sampling Time |
End of shift |
|
BEI |
15 mg/l |
|
Notation
|
B, C
|
|
Determinant |
Formic acid in urine |
|
Sampling Time |
Prior to last shift of workweek |
|
BEI |
80 mg/g creatinine |
|
Notation |
B, C |
Methemoglobin inducers
|
Determinant |
Methemeglobin in blood |
|
Sampling Time |
During or end of shift |
|
BEI |
1.5% of hemoglobin |
|
Notation |
B, C , D |
Methyl Chloroform
|
Determinant |
Methyl chloroform in end exhaled air |
|
Sampling Time |
Prior to last shift of workweek |
|
BEI |
40 ppm |
|
Determinant |
Trichloroacetic acid in urine |
|
Sampling Time |
End of workweek |
|
BEI |
10 mg/l |
|
Notation
|
C, D
|
|
Determinant |
Total trichloroethanol in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
30 mg/l |
|
Notation
|
C, D
|
|
Determinant |
Total trichloroethanol in blood |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
1 mg/l |
|
Notation |
C |
Methyl Ethyl Ketone (MEK)
|
Determinant |
MEK in urine |
|
Sampling Time |
End of shift |
|
BEI |
2 mg/l |
Methyl isobutyl ketone (MIBK)
|
Determinant |
MIBK in urine |
|
Sampling Time |
End of shift |
|
BEI |
2 mg/l |
Nitrobenzene
|
Determinant |
Total p-nitrophenol in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
5 mg/g creatinine |
|
Notation
|
C
|
|
Determinant |
Methemoglobin in blood |
|
Sampling Time |
End of shift |
|
BEI |
1.5% of hemoglobin |
|
Notation |
B, C , D |
Organophosphorus Cholinesterase Inhibitors
|
Determinant |
Cholinesterase activity in red cells |
|
Sampling Time |
Discretionary |
|
BEI |
70% of individual's baseline |
|
Notation |
B, C , D |
Parathion
|
Determinant |
Total p-nitrophenol in urine |
|
Sampling Time |
End of shift |
|
BEI |
0.5 mg/g creatinine |
|
Notation
|
C , D
|
|
Determinant |
Cholinesterase activity in red cells |
|
Sampling Time |
Discretionary |
|
BEI |
70% of individuals baseline |
|
Notation |
B, C , D |
Pentachlorophenol
|
Determinant |
Total PCP in urine |
|
Sampling Time |
Prior to the last shift of workweek |
|
BEI |
2 mg/g creatinine |
|
Notation
|
B
|
|
Determinant |
Free PCP in plasma |
|
Sampling Time |
End of shift |
|
BEI |
5 mg/l |
|
Notation |
B |
Perchloroethylene
|
Determinant |
Perchloroethylene in end-exhaled air |
|
Sampling Time |
Prior to the last shift of workweek |
|
BEI |
10 ppm |
|
Determinant |
Perchloroethylene in blood |
|
Sampling Time |
Prior to the last shift of workweek |
|
BEI |
1 mg/l |
|
Determinant |
Trichloroacetic acid in urine |
|
Sampling Time |
End of workweek |
|
BEI |
7 mg/l |
|
Notation |
C , D |
Phenol
|
Determinant |
Total phenol in urine |
|
Sampling Time |
End of shift |
|
BEI |
250 mg/g creatinine |
|
Notation |
B, C |
Styrene
|
Determinant |
Mandelic acid in urine |
|
Sampling Time |
End of shift |
|
BEI |
800 mg/g creatinine |
|
Notation
|
C
|
|
Sampling Time |
Prior to next shift |
|
BEI |
300 mg/g creatinine |
|
Notation
|
C
|
|
Determinant |
Phenolglyoxylic acid in urine |
|
Sampling Time |
End of shift |
|
BEI |
240 mg/g creatinine |
|
Notation
|
B, C
|
|
Sampling Time |
Prior to next shift |
|
BEI |
100 mg/g creatinine |
|
Notation
|
B, C
|
|
Determinant |
Styrene in venous blood |
|
Sampling Time |
End of shift |
|
BEI |
0.55 mg/l |
|
Notation
|
D
|
|
Sampling Time |
Prior to next shift |
|
BEI |
0.02 mg/l |
|
Notation |
DD |
Toluene
|
Determinant |
Hippuric acid in urine |
|
Sampling Time |
End of shift Last 4 hours of shift |
|
BEI |
2.5 g/g creatinine |
|
Notation
|
B, C
|
|
Determinant |
Toluene in venous blood |
|
Sampling Time |
End of shift |
|
BEI |
1 mg/l |
|
Notation
|
D
|
|
Determinant |
o-Cresol in urine |
|
Sampling Time |
End of shift |
|
BEI |
1 mg/g creatinine |
|
Notation
|
C
|
Trichloroethylene
|
Determinant |
Trichloroacetic acid in urine |
|
Sampling Time |
End of workweek |
|
BEI |
100 mg/g creatinine |
|
Notation
|
C
|
|
Determinant |
Trichloroacetic acid and trichloroethanol in urine |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
300 mg/g creatinine |
|
Notation
|
C |
|
Determinant |
Free trichloroethanol in blood |
|
Sampling Time |
End of shift at end of workweek |
|
BEI |
4 mg/l |
|
Notation
|
C
|
|
Determinant |
Trichloroethylene in end-exhaled air |
|
Notation |
D |
Xylenes
|
Determinant |
Methylhippuric acid in urine |
|
Sampling Time |
End of shift Last 4 hours of shift |
|
BEI |
1.5 g/g creatinine |
|
Notation |
2 mg/min |
